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International Review of Education - While European education systems fundamentally rest on a rather monolithic world-view, some of them are explicitly oriented towards Christianity and others are...  相似文献   
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In this study, we examined the effect of two metacognitive scaffolds on the accuracy of confidence judgments made while diagnosing dermatopathology slides in SlideTutor. Thirty-one (N = 31) first- to fourth-year pathology and dermatology residents were randomly assigned to one of the two scaffolding conditions. The cases used in this study were selected from the domain of nodular and diffuse dermatitides. Both groups worked with a version of SlideTutor that provided immediate feedback on their actions for 2 h before proceeding to solve cases in either the Considering Alternatives or Playback condition. No immediate feedback was provided on actions performed by participants in the scaffolding mode. Measurements included learning gains (pre-test and post-test), as well as metacognitive performance, including Goodman–Kruskal Gamma correlation, bias, and discrimination. Results showed that participants in both conditions improved significantly in terms of their diagnostic scores from pre-test to post-test. More importantly, participants in the Considering Alternatives condition outperformed those in the Playback condition in the accuracy of their confidence judgments and the discrimination of the correctness of their assertions while solving cases. The results suggested that presenting participants with their diagnostic decision paths and highlighting correct and incorrect paths helps them to become more metacognitively accurate in their confidence judgments.  相似文献   
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Determination of amyloid β (Aβ) isoforms and in particular the proportion of the Aβ 1-42 isoform in cerebrospinal fluid (CSF) of patients suspected of Alzheimer's disease might help in early diagnosis and treatment of that illness. Due to the low concentration of Aβ peptides in biological fluids, a preconcentration step prior to the detection step is often necessary. This study utilized on-chip immunoprecipitation, known as micro-immunoprecipitation (μIP). The technique uses an immunosorbent (IS) consisting of magnetic beads coated with specific anti-Aβ antibodies organized into an affinity microcolumn by a magnetic field. Our goal was to thoroughly describe the critical steps in developing the IS, such as selecting the proper beads and anti-Aβ antibodies, as well as optimizing the immobilization technique and μIP protocol. The latter includes selecting optimal elution conditions. Furthermore, we demonstrate the efficiency of anti-Aβ IS for μIP and specific capture of 5 Aβ peptides under optimized conditions using various subsequent analytical methods, including matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF-MS), capillary electrophoresis, microchip electrophoresis, and immunoblotting. Synthetic Aβ peptides samples prepared in buffer and spiked in human CSF were analyzed. Finally, on-chip immunoprecipitation of Aβ peptides in human CSF sample was performed.  相似文献   
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Abstract

As access to the Internet has become increasingly essential for social and economic participation, public domain Internet measurements have become indispensable for users to validate quality of service their network operator delivers and for policymakers to identify and address gaps in broadband infrastructure. This article evaluates public domain Internet performance measurements available for assessing the state of connectivity and developing universal access service quality standards in Canada. The analysis suggests that different approaches to Internet measurement represent complementary windows into a complex and fast evolving reality of broadband connectivity. Despite their potential shortcomings, large-scale crowdsourced open data network testing platforms have a central role to play in enabling broadband infrastructure policy coordination across different levels of government, empowerment of consumers, and achievement of universal service objectives for quality of service users experience when accessing the open Internet.  相似文献   
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This paper deals with observer-based control design for a class of switched discrete-time linear systems with parameter uncertainties. The main contribution of the paper is to propose a convenient way based on Finsler’s lemma to enhance the synthesis conditions, expressed in terms of Linear Matrix Inequalities (LMIs). Indeed, this judicious use of Finsler’s lemma provides additional decision variables, which render the LMIs less conservative and more general than all those existing in the literature for the same class of systems. Two numerical examples followed by a Monte Carlo evaluation are proposed to show the superiority of the proposed design technique.  相似文献   
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Conditions are given for underdamped or overdamped linear dynamical systems in terms of loop matrix parameters, (√(C)R√(C)g,g)2 ? 4(√(C)L√(C)g,g) for all [boxV]g[boxV] = 1, g ∈ H. These criteria are looked upon as natural generalizations of the elementary one-loop RLC series scalar criteria (R/2L)2 ? 1/LC, when written in the more suggestive form: (√(C)R√(C))2 ? 4√(C)L√(C). A simplified test for determining dynamical systems with all complex natural modes or all real modes are presented with additional comments.  相似文献   
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In this paper two robust controllers for a multivariable vertical short take-off and landing (VSTOL) aircraft system are designed and compared. The aim of these controllers is to achieve robust stability margins and good performance in step response of the system. LQG/LTR method is a systematic design approach based on shaping and recovering open-loop singular values while mixed-sensitivity H method is established by defining appropriate weighting functions to achieve good performance and robustness. Comparison of the two controllers show that LQG method requires rate feedback to increase damping of closed-loop system, while H controller by only proper choose the weighting functions, meets the same performance for step response. Output robustness of both controllers is good but H controller has poor input stability margin. The net controller order of H is higher than the LQG/LTR method and the control effort of them is in the acceptable range.  相似文献   
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